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Publications
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On a mission to discover and develop new therapies for various diseases, Boehringer Ingelheim researchers also author many scientific publications a year. These publications are part of a commitment to improve scientific knowledge by sharing critical and innovative research with the scientific community.
Below is a list of recent publications by Boehringer Ingelheim employees:
Song JJ; Gallou F; Reeves JT; Tan Zh; Yee NK; Senanayake ChH, Activation of TMSCN by N-Heterocyclic Carbenes for Facile Cyanosilylation of Carbonyl compounds. J Org Chem 71 (3), 1273-1276 (2006)
Fisher MB; Henne KR; Boer. The complexities inherent in attempts to decrease drug clearance by blocking sites of CYP-mediated metabolism. J Curr Opin Drug Discov Dev 9 (1), 101-109 (2006)
Hayashi M; Imanaka-Yoshida K; Yoshida T; Wood M; Fearns C; Tatake RJ; Lee JD. A crucial role of mitochondrial Hsp40 in preventing dilated cardiomyopathy. Nature Med 12 (1), 128-132 (2006)
Wang X-J; Sun X; Zhang L; Xu Y; Krishnamurthy D; Senanayake ChH. Noncryogenic I/Br-Mg exchange of aromatic halides bearing sensitive functional groups using i-PrMgCl-Bis[2-(N,N-dimethylamino)ethyl] ether complexes. Org Lett 8 (2), 305-307 (2006)
Taylor StJ; Netherton MR. Synthesis of the benzhydryl motif via a Suzuki-Miyaura coupling of arylboronic acids and 3-chloroacrylonitriles. J Org Chem 71 (1), 397-400 (2006)
Lee ThW; Proudfoot JR; Thomson DS. A concise asymmetric route for the synthesis of a novel class of glucocorticoid mimetics containing a trifluoromethyl-substituted alcohol. Bioorg Med Chem Lett 16 (3), 654-657 (2006)
Kaplita PV; Hu H; Liu L; Farrell TM; Grbic H; Spero DM. Automatable formats of higher throughput ADMET profiling for drug discovery support. J Assoc Lab Automat 10 (3), 140-148 (2005)
Qian KC; Studts J; Wang L; Barringer K; Kronkaitis A; Peng Ch; Baptiste A; LaFrance R; Mische Sh; Farmer B. Expression, purification, crystallization and preliminary crystallographic analysis of human Pim-1 kinase. Acta Crystallogr (F) F61 (1). 96-99 (2005)
Proudfoot JR. The evoluation of synthetic oral drug properties. Bioorg Med Chem Lett 15 (4), 1087-1090 (2005)
Jianfei Yang, Brian E. Castle, Adedayo Hanidu, Lisa Stevens, Yang Yu, Xiang Li, Carol Stearns, Vladimir Papov, Daniel Rajotte, and Jun Li. Sphingosine Kinase 1 Is a Negative Regulator of CD4+ Th1 Cells. J Immunol 175 (10), 6580-6588 (2005)
Davidson W; Frego L; Peet GW; Kroe RR; Labadia ME; Lukas SM; Snow RJ; Jakes S; Grygon CA; Werneburg BG. Discovery and characterization of a substrate selective p38alpha inhibitor. Biochemistry 43 (37), 11958-11971 (2004)