 |
Technologies
|
Technologies are an integral part of Research and Development. Departments such as Biologics and Biomolecular Sciences, Drug Discovery Support, Translational Sciences, and Medicinal Chemistry play a pivotal role in the progression of drug candidates to novel therapies.
- Biologics and Biomolecular Sciences
- Drug Discovery Support
- Translational Sciences
- Medicinal Chemistry
Biologics and Biomolecular Sciences
The Ridgefield, Connecticut research site utilizes state-of-the-art technology for studying biomolecular interactions. Expertise in physical, biological, analytical, and mathematical sciences are applied toward studies for potential new drug candidates. Fluorescence-based imaging and cytometric technologies are employed to characterize potential drug candidates. The kinetic, thermodynamic and equilibrium binding properties of drug candidates with their protein targets, as well as their structural effects, are studied to understand target compound interactions.
Drug Discovery Support
The goal of the Drug Discovery Support (DDS) department is to continually improve the quality of drug candidates that move from Discovery into Development. To achieve this goal, the department focuses in three main areas: Drug Metabolism & Pharmacokinetics (DMPK), Pharmaceutics and General Pharmacology. As a highly motivated, diverse team of professionals, DDS relies heavily on close interactions between our respective groups, with the Discovery project teams and with all departments to ensure that the highest quality compounds move forward into Development.
Translational Sciences
The first step in the drug discovery process is to identify a protein target involved in a disease. The Translational Sciences department has the responsibility for the production of target proteins for research purposes. The proteins made by this group are supplied to all areas of the drug discovery process. The Translational Sciences department also includes the Transgenic and Genomics groups which, in close association with the Bioinformatics team, are responsible for supporting target identification, validation and lead optimization of potential drug candidates.
Medicinal Chemistry
The Medicinal Chemistry department is responsible for discovering and optimizing small molecules for the treatment of cardiovascular and immunological/inflammatory diseases. Candidate molecules are discovered in the biomolecular screening group, which performs biochemical assays. Lead optimization and identification groups optimize the molecules into potential drug candidates for human therapy. The process is aided by the structural research group which utilizes state of the art technologies to support lead optimization and lead identification programs.